GreatMod - Multiple Sclerosis

Multiple Sclerosis Model

In Figure is showed the ESSN model representing the cellular interactions characterizing the immunopa-thology of RRMS. The model consists of 26 places and 55 transitions, of these 42 are standard and 15 general. In details, the model is divided in two compartments: the peripheral lymph node/blood vessel and the CNS. The two compartments interact with each other through the place BBB. All the transitions describing interactions occurring in peripheral lymph node/blood vessel have the suffix _out while all the transitions taking place in CNS have the suffix _in.

A detailed description of the model is reported in [1].

• [1] Computational modeling of the immune response in multiple sclerosis using epimod framework. S. Pernice, L. Follia, A. Maglione, M. Pennisi, F. Pappalardo, F. Novelli, M. Clerico, M. Beccuti, F. Cordero, S. Rolla. BMC Bioinformatics, Volume 21, Article number: 550 (2020).